The ovary is one of two glands in the female reproductive system that produces the reproductive cell and the hormones, estrogen and progesterone. Atrophy is a wasting or decrease in size of an organ or tissue.

Causative factors related to hormonal atrophy of the ovaries include: menopause; malnutrition; anatomic abnormalities; endocrine disorders; or genetic defects. In addition, chemotherapy, and radiation of the pelvis may also cause ovarian atrophy.

There may be absence of menstruation or infertility. Hot flashes, excess perspiration, fatigue, irritability, insomnia, depression, memory loss, inability to concentrate, headache, anxiety or nervousness may be evident. There may also be dizziness, palpitations, nausea, changes in bowel and bladder function, and changes in the lower genital area.

Complete physical examination, papanicolaou (PAP) smear, and mammogram may be done prior to treatment. Laboratory studies may also be indicated.

Oral or transdermal vaginal hormone replacement therapy (HRT) may be given. In certain genetic disorders, surgery may be indicated because of the possibility of cancer occurring.

Possible development of heart disease, stroke, and osteoporosis may increase. There is an increased potential to develop endometrial cancer in women who have a uterus and who take estrogen replacement therapy. Certain genetic disorders may result in cancer. Ongoing physical examinations and mammograms may be necessary. Counseling, psychotherapy, and support groups may be indicated to assist the patient in dealing with the diagnosis.